a20 (Santa Cruz Biotechnology)
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Structured Review
Santa Cruz Biotechnology
a20
A20, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 94/100, based on 372 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/a20/A20+Antibody/pm42875598-256-77-80
Average 94 stars, based on 372 article reviews
A20, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 94/100, based on 372 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/a20/A20+Antibody/pm42875598-256-77-80
Average 94 stars, based on 372 article reviews
a20 - by Bioz Stars,
2026-10
94/100 stars
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Recombinant:Article Title: CYLD links the TRAF6/sNASP axis to TLR4 signaling in sepsis-induced acute lung injury. Article Snippet: .. The following antibodies and recombinant proteins were utilized: CYLD (SC-74435, Santa Cruz, Dallas, TX, USA), Article Title: CYLD links the TRAF6/sNASP axis to TLR4 signaling in sepsis-induced acute lung injury Article Snippet: .. The following antibodies and recombinant proteins were utilized: CYLD (SC-74435, Santa Cruz, Dallas, TX, USA), Ubiquitin Proteomics:Article Title: CYLD links the TRAF6/sNASP axis to TLR4 signaling in sepsis-induced acute lung injury. Article Snippet: .. The following antibodies and recombinant proteins were utilized: CYLD (SC-74435, Santa Cruz, Dallas, TX, USA), Article Title: CYLD links the TRAF6/sNASP axis to TLR4 signaling in sepsis-induced acute lung injury Article Snippet: .. The following antibodies and recombinant proteins were utilized: CYLD (SC-74435, Santa Cruz, Dallas, TX, USA), Article Title: USP25 augments XIAP-mediated signaling to safeguard intestinal homeostasis. Article Snippet: Nucleotide-binding oligomerization domain containing 2 (NOD2) recognizes conserved bacterial components in the cytoplasm to initiate innate immune responses, and its mutations are closely associated with Crohn’s disease (CD).. Here, we discover that the NOD2 signaling is regulated by the deubiquitinase USP25.. Macrophages lacking USP25 exhibit impaired NOD2 signaling and are defective in cytokine production upon stimulation with muramyl dipeptide (MDP). other:Article Title: A TAK1 cytokine toxicity checkpoint controls anti-cancer immunity. Article Snippet: Proportion of live cells within each labeled population was assessed based on BFP or mCherry expression using the BD FACS Symphony Cell Analyzer. Article Title: The TRIF-RIPK1-Caspase-8 signalling in the regulation of TLR4-driven gene expression. Article Snippet: Correspondence Yang Mi, Department of Biochemistry and molecular biology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, China.. Email: miyang@zzu.edu.cn Abstract The inflammatory response is tightly regulated to eliminate invading pathogens and avoid excessive production of inflammatory mediators and tissue damage.. Caspase-8 is a cysteine protease that is involved in programmed cell death. SDS Page:Article Title: MALT1 promotes necroptosis in stroke rat brain via targeting the A20/RIPK3 pathway. Article Snippet: Necroptosis has been demonstrated to contribute to brain injury in ischemic stroke, whereas A20 can exert antinecroptosis effect via deubiquitinating receptor-interacting protein kinase (RIPK3) at k63 and it can be cleaved by MALT1.. This study aims to explore whether MALT1 is upregulated in the brain during ischemic stroke and promotes brain cell necroptosis through enhancing the degradation of A20.. Ischemic stroke model was established in Sprague Dawley rats by occlusion of the middle cerebral artery (MCA) for 2 h, followed by 24 h reperfusion, which showed brain injury (increase in neurological deficit score and infarct volume) concomitant with an upregulation of MALT1, a decrease in A20 level, and increases in necroptosis-associated protein levels [RIPK3, mixed lineage kinase domain-like protein (MLKL) and p-MLKL] and k63-ubiquitination of RIPK3 in brain tissues. Incubation:Article Title: MALT1 promotes necroptosis in stroke rat brain via targeting the A20/RIPK3 pathway. Article Snippet: Necroptosis has been demonstrated to contribute to brain injury in ischemic stroke, whereas A20 can exert antinecroptosis effect via deubiquitinating receptor-interacting protein kinase (RIPK3) at k63 and it can be cleaved by MALT1.. This study aims to explore whether MALT1 is upregulated in the brain during ischemic stroke and promotes brain cell necroptosis through enhancing the degradation of A20.. Ischemic stroke model was established in Sprague Dawley rats by occlusion of the middle cerebral artery (MCA) for 2 h, followed by 24 h reperfusion, which showed brain injury (increase in neurological deficit score and infarct volume) concomitant with an upregulation of MALT1, a decrease in A20 level, and increases in necroptosis-associated protein levels [RIPK3, mixed lineage kinase domain-like protein (MLKL) and p-MLKL] and k63-ubiquitination of RIPK3 in brain tissues. Western Blot:Article Title: IRE1 RNase controls CD95-mediated cell death Article Snippet: .. The following primary antibodies were used for western blot: CD95 (Cell signalling, 4233, AB_2100359), Actin (Sigma-Aldrich, A5316, AB_476743), IRE1 (Cell signalling, 3294, AB_823545 and Santa Cruz, 390960, AB_2936473), XBP1s (Biolegend, 647502, AB_2241743), Caspase-8 (Adipogen, AG-20B-0057-C100, AB_2490271), Caspase-3 (Cell signalling, 14220, AB_2798429), Cleaved caspase-3 (Cell signalling, 9661, AB_2341188), FADD (Cell signalling, 2782, AB_2100484), PUMA (Cell signalling, 12450, AB_2797920), BAX (Cell signalling, 5023, AB_10557411), BAK (Cell signalling, 12105, AB_2716685), BID (Cell signalling, 2002, AB_10692485), Caspase-7 (Cell signalling, 12827, AB_2687912), Caspase-9 (Cell signalling, 9502, AB_2068621), HOIP (Ubiquigent, 68-0013-100), CYLD (Santa Cruz, sc-74435, AB_1122022), Cell-Signaling:Article Title: USP25 augments XIAP-mediated signaling to safeguard intestinal homeostasis. Article Snippet: Nucleotide-binding oligomerization domain containing 2 (NOD2) recognizes conserved bacterial components in the cytoplasm to initiate innate immune responses, and its mutations are closely associated with Crohn’s disease (CD).. Here, we discover that the NOD2 signaling is regulated by the deubiquitinase USP25.. Macrophages lacking USP25 exhibit impaired NOD2 signaling and are defective in cytokine production upon stimulation with muramyl dipeptide (MDP). FLAG-tag:Article Title: USP25 augments XIAP-mediated signaling to safeguard intestinal homeostasis. Article Snippet: Nucleotide-binding oligomerization domain containing 2 (NOD2) recognizes conserved bacterial components in the cytoplasm to initiate innate immune responses, and its mutations are closely associated with Crohn’s disease (CD).. Here, we discover that the NOD2 signaling is regulated by the deubiquitinase USP25.. Macrophages lacking USP25 exhibit impaired NOD2 signaling and are defective in cytokine production upon stimulation with muramyl dipeptide (MDP). Hemagglutination Assay:Article Title: USP25 augments XIAP-mediated signaling to safeguard intestinal homeostasis. Article Snippet: Nucleotide-binding oligomerization domain containing 2 (NOD2) recognizes conserved bacterial components in the cytoplasm to initiate innate immune responses, and its mutations are closely associated with Crohn’s disease (CD).. Here, we discover that the NOD2 signaling is regulated by the deubiquitinase USP25.. Macrophages lacking USP25 exhibit impaired NOD2 signaling and are defective in cytokine production upon stimulation with muramyl dipeptide (MDP). |